2005–2006: Hiatus

In 2005, some industry insiders speculated that Eminem was considering ending his rapping career after six years and several multi-platinum albums. Speculation began in early 2005 about a double-disc album to be released late that year, rumored to be titled The Funeral.

The album manifested itself as a compilation album under the name Curtain Call: The Hits, and was released on December 6, 2005 under Aftermath Entertainment. In July 2005, the Detroit Free Press broke news of a potential final bow for Eminem as a solo performer, quoting members of his inside circle who said that he will begin to fully embrace the role of producer and label executive.

On December 6, 2005, the day Curtain Call: The Hits was released, Eminem denied that he was retiring on Detroit-based WKQI's "Mojo in the Mornin'" radio show, but implied that he would at least be taking a break as an artist, saying "I'm at a point in my life right now where I feel like I don't know where my career is going… This is the reason that we called it 'Curtain Call,' because this could be the final thing. We don't know."

That year, Eminem was a subject of criticism in conservative Bernard Goldberg's book 100 People Who Are Screwing Up America, being ranked at #58. Goldberg cited a 2001 column by Bob Herbert of The New York Times claiming, "In Eminem's world, all women are whores and he is eager to rape and murder them." The Eminem song "No One's Iller" was used by Goldberg as an example of misogyny in his music.

In summer 2005, Eminem embarked on his first U.S. concert run in three years, the Anger Management 3 Tour, featuring Lil' Jon, 50 Cent and G-Unit, D12, Obie Trice, The Alchemist, and others. In August 2005, Eminem canceled the European leg of the tour and subsequently announced that he had entered drug rehabilitation for treatment for a "dependency on sleep medication".

On December 5, 2006, Eminem released an album compilation entitled Eminem Presents the Re-Up. It started out as a mixtape but Eminem found that the material was better than expected and released it as a full album. It was meant to help launch new Shady Records artists Stat Quo, Cashis, and Bobby Creekwater.